2-[(2R, 6S)-6-[(2S)-... 申请号：CN201610891476.8 专利类型：发明授权 公开（公告）日：2016-10-12
状态：寻求转化 转让价格：面议
本发明公开了2‑[(2R，6S)‑6‑[(2S)‑2‑羟基‑2‑苯乙基]‑1‑甲基哌啶]‑1‑苯乙酮的合成方法，属于有机合成领域。本发明先采用(1S，2S)‑1，2‑二苯基乙二胺为原料经过酰化、取代等三步制备手性胺催化剂；主路线总共两步，采用戊二醛、苯甲酰乙酸、甲胺盐酸盐合成出顺式山梗烷酮，在催化剂的作用下，通过温和的反应条件进行不对称选择性还原合成2‑[(2R，6S)‑6‑[(2S)‑2‑羟基‑...
2-SUBSTITUTED PYRAZO... 申请号：WOCN18106694 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
The present invention relates to a novel compound as a JAK inhibitor, a composition, and an application thereof. Specifically, the present invention provides a compound having high AK inhibitory ac...
2-OXO-5H-CHROMENO[4,... 申请号：WOEP18082540 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
The present invention discloses compounds according to Formula (I), wherein R1, R2a, R2b, R3, R4, and R5 are as defined herein. The present invention relates to compounds, methods for their pro...
2-BENZOYLAMINOBENZAM... 申请号：US16593147 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
The invention relates to a compound of general formula (I) : wherein R1, R2, R3, R4, Q, m and n are as defined herein. The compounds are inhibitors of Bcl-3 and are useful for the treatment of ca...
2-BENZOYLAMINOBENZAM... 申请号：US16593147 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
The invention relates to a compound of general formula (I) : wherein R1, R2, R3, R4, Q, m and n are as defined herein. The compounds are inhibitors of Bcl-3 and are useful for the treatment of ca...
2-AZABICYCLO[3.1.1] ... 申请号：WOGB18053093 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
There is provided a compound of formula I, wherein L1, R1, R2, R5, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, whi...
2-ARYLIMIDAZO[1, 2-B... 申请号：CA2821546 专利类型：发明授权 公开（公告）日：2011-12-22
状态：寻求转化 转让价格：面议
Disclosed are compounds of formula (I) : (Formula (I) where X, Y, X, A, R1; R2, and R3 are defined herein. Also disclosed are pharmaceutically acceptable salts of the compounds, compositions c...
2-APB在制备抗脑血管疾病药物中的应用 申请号：CN201811155515.3 专利类型：发明申请 公开（公告）日：2018-09-30
状态：寻求转化 转让价格：面议
本发明公开了2‑氨基乙氧基二苯基硼酸盐(2‑APB)在制备抗脑血管疾病药物中的应用，属于生物医药技术领域。本发明首次在神经元糖氧剥夺模型中研究了2‑APB对缺血性脑卒中的保护作用，且首次提出了2‑APB减少神经元死亡的作用机制与抑制氧化应激及Wnt/Ca2+信号转导通路有关，证明了2‑APB对缺血性神经元具有保护作用，能够减少缺血性脑卒中患者脑损伤。这些进一步补充和丰富了神经元保护机制的相关研究，...
