3, 3`, 4, 4`-联苯四甲酸的合... 申请号:CN201911136906.5 专利类型:发明申请 公开(公告)日:
状态:寻求转化 转让价格:面议
本发明公开了一种3, 3' , 4, 4' ‑联苯四甲酸的合成方法,它是以4, 4' ‑二甲基联苯为起始原料,先与式Ⅰ的环状酸酐进行傅克酰基化反应得到中间体Ⅱ,再经氧化反应得到3, 3' , 4, 4' ‑联苯四甲酸,式Ⅰ的环状酸酐为丁二酸酐、戊二酸酐、己二酸酐或者马来酸酐。本发明的方法无需价格昂贵的催化体系,大大降低了合成3, 3' , 4, 4' ‑联苯四甲酸的生产成本;本发明的方法操作简单,...
3, 3`, 4, 4`-联苯四甲酸的合... 申请号:CN201911136906.5 专利类型:发明申请 公开(公告)日:
状态:寻求转化 转让价格:面议
本发明公开了一种3, 3' , 4, 4' ‑联苯四甲酸的合成方法,它是以4, 4' ‑二甲基联苯为起始原料,先与式Ⅰ的环状酸酐进行傅克酰基化反应得到中间体Ⅱ,再经氧化反应得到3, 3' , 4, 4' ‑联苯四甲酸,式Ⅰ的环状酸酐为丁二酸酐、戊二酸酐、己二酸酐或者马来酸酐。本发明的方法无需价格昂贵的催化体系,大大降低了合成3, 3' , 4, 4' ‑联苯四甲酸的生产成本;本发明的方法操作简单,...
3, 3, 3-三氟-2, 2-二甲基丙... 申请号:CN201811060961.6 专利类型:发明申请 公开(公告)日:2018-09-12
状态:寻求转化 转让价格:面议
本发明涉及3, 3, 3‑三氟‑2, 2‑二甲基丙酸的合成方法,步骤如下:容器内加入2‑三氟甲基‑2‑丙醇和乙腈,降温并加入氢化钠,保温反应后,加入对甲苯磺酰氯进行反应,然后水洗分液,对得到的有机相进行干燥,得中间体1;容器内加入中间体1、氰化钠和二甲基甲酰胺,加热进行回流反应,反应完毕后水洗分液,对有机相进行浓缩和精馏,收集55‑58℃馏分,得到中间体2;中间体2加入氢氧化钠水溶液中,搅拌均匀,...
3, 5 - Disubstitute... 申请号:JP2018541333 专利类型:发明申请 公开(公告)日:
状态:寻求转化 转让价格:面议
Potent inhibitors of Chk1 have the structure formula (I) below. Pharmaceutical compositions comprising the Chk1 inhibitors, uses thereof and their preparation process.
3, 5 - Diphenyl - d... 申请号:JP2018532323 专利类型:发明申请 公开(公告)日:2016-12-14
状态:寻求转化 转让价格:面议
The therapeutic effect is caused by the inhibition of the protein aggregation in the affected tissue, such as the brain. 3, 5-Diphenyl-diazole derivatives have been shown to be effective in inhibitin...
3, 4 - [...] deriva... 申请号:JP2019523621 专利类型:发明申请 公开(公告)日:
状态:寻求转化 转让价格:面议
The present invention relates to a 3, 4-bipyridyl pyrazole derivative, and a preparation method therefor and a medical application thereof. Specifically, the present invention relates to a new 3, 4-...
3, 4 - [...] deriva... 申请号:JP2019523621 专利类型:发明申请 公开(公告)日:
状态:寻求转化 转让价格:面议
The present invention relates to a 3, 4-bipyridyl pyrazole derivative, and a preparation method therefor and a medical application thereof. Specifically, the present invention relates to a new 3, 4-...
3, 3 - Difluoro -2 ... 申请号:JP2015066966 专利类型:发明授权 公开(公告)日:2015-03-27
状态:寻求转化 转让价格:面议
Disclosed is a practical method for production of 3, 3-difluoro-2-hydroxypropionic acid, which is important as pharmaceutical and agrichemical intermediates. The method includes forming a 4, 4-difluo...
3 dimensional ナビゲーショ... 申请号:JP2001532374 专利类型:发明申请 公开(公告)日:
状态:寻求转化 转让价格:面议
A user interface, system, method and software for displaying a simulated three-dimensional display of menu options to a user, thereby maximizing use of a display' s real estate by presenting all av...
3 Kinds of antiviral... 申请号:JP2018562617 专利类型:发明申请 公开(公告)日:
状态:寻求转化 转让价格:面议
Disclosed are pharmaceutical compositions comprising three antiviral compounds. In particular, the pharmaceutical compositions comprise an effective amount of velpatasvir, an effective amount of sof...