ALOX12抑制剂在制备缺血再灌注损伤治... 申请号：CN201710719319.3 专利类型：发明授权 公开（公告）日：
状态：寻求转化 转让价格：面议
本发明通过研究发现，在肝脏缺血再灌注损伤中，ALOX12蛋白表达量和mRNA表达量的变化显著，而ALOX5和ALOX15的变化没有差异，表明ALOX12与其它ALOX成员相比，对肝脏缺血再灌注损伤的作用更大。ALOX12过表达会加重缺氧和复氧处理引起的肝细胞、肾脏细胞的活性降低，促进肝脏细胞的炎症反应；并且，ALOX12低表达能缓解缺氧和复氧处理引起的心肌细胞活性降低，这些结果表明ALOX12可促...
ALMIGHTY SUB-CONTROL... 申请号：WOCN10002096 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
An almighty sub-controlled low-carbon water faucet is disclosed. The front part of the water faucet shell (1) is provided with a cover (2) through the center of which is a water outlet (3), and the i...
ALK蛋白降解剂及其抗肿瘤应用 申请号：CN201811519739.8 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
本发明公开了式(I)的化合物及其抗肿瘤应用。式(I)化合物对ALK靶蛋白具有降解和抑制作用，其主要由四部分组成，第一部分ALK‑TKIs是具有ALK酪氨酸激酶抑制活性的化合物；第二部分LIN是不同链接单元(Linker)；第三部分ULM是具有泛素化功能的VHL、CRBN或者其它蛋白酶的小分子配体(ULM, ubiquitin ligase binding moiety)；以及第四部分基团A为羰基或...
ALKYNYLPYRIDINE INHI... 申请号：RU2018113258 专利类型：发明授权 公开（公告）日：
状态：寻求转化 转让价格：面议
FIELD : chemistry.SUBSTANCE : present invention relates to pharmaceutical chemistry. In particular, the present invention relates to a class of alkynylpyridine inhibitors (I) prolyl hydroxylase. Ex...
ALKYNYL-SUBSTITUTED ... 申请号：MX2019003143 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
The present invention relates to an alkynyl-substituted heterocyclic compound acting as an FGFR inhibitor, a preparation method therefor and the medical use thereof. In particular, the present inven...
ALKYNYL(HETERO)AROMA... 申请号：WOCN19093469 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
Provided is an alkynyl(hetero)aromatic compound having an inhibitory effect to protein tyrosine kinase, a pharmaceutical composition comprising same, preparation and usage thereof. Specifically, di...
ALKYNYL(HETERO)AROMA... 申请号：WOCN19093469 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
Provided is an alkynyl(hetero)aromatic compound having an inhibitory effect to protein tyrosine kinase, a pharmaceutical composition comprising same, preparation and usage thereof. Specifically, di...
ALKYNYL (HETERO) ARO... 申请号：WOCN19096062 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
Disclosed are alkynyl (hetero) aromatic ring compounds that inhibit protein tyrosine kinases, pharmaceutical compositions comprising same, preparations therefor and uses thereof. Specifically, disc...
ALKYNYL (HETERO) ARO... 申请号：WOCN19096062 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
Disclosed are alkynyl (hetero) aromatic ring compounds that inhibit protein tyrosine kinases, pharmaceutical compositions comprising same, preparations therefor and uses thereof. Specifically, disc...
ALK PROTEIN DEGRADAT... 申请号：WOCN18120745 专利类型：发明申请 公开（公告）日：
状态：寻求转化 转让价格：面议
Disclosed by the present invention are a compound represented by formula (I) and an anti-tumor application thereof. The compound represented by formula (I) has a degrading and inhibiting effect on an ...
