The present invention provides a system and method for interactive integration of electronic patient medical records, the system and method having a central personal health record database networked to one or more local medical records maintained by individual health care providers, wherein the central personal health records and the local medical records have compatible electronic data structures, there being a personal health record and at least one local medical record corresponding to each particular patient. Each health care provider may be associated by a particular patient with the personal health record corresponding to the patient, and each health care provider may be enabled to access the personal health record for downloading and synchronization with a corresponding local medical record maintained by the health care provider, and may further be enabled to upload and synchronize changes made in a local medical record back to the corresponding personal health record.