A system and method determine and report a potential for development by a patient of disease and adverse health conditions. The method includes receiving patient phenotype data. The phenotype data can include, but is not limited to, biometric data specific to the patient, medical claims data specific to the patient, and organizational data specific to an organization to which the patient belongs. One or more predictive models are generated using one or more algorithms executing on at least one processor of a computing apparatus. The one or more predictive models determine and indicate the potential for development by the patient of disease and adverse health conditions, and output the potential to a user.