The invention discloses a virtual panorama-based intelligent tourist guide service system which comprises a three-dimensional digital scenic spot modeling module, a virtual tourism scene creation module, a streaming media service and transmission module and a user interaction module. According to the system disclosed by the invention, tourism information of specific scenic spots in a scenic region corresponds to scenic spot positioning data by utilizing a three-dimensional digital panoramic technology, a virtual reality technology, a navigational positioning technology, a multimedia technology, a mobile internet technology, a cloud storage technology and the like, tourists can autonomously operate interested digital real scenes and experience the cultural tourism charm like staying on the scene, ' static' tourism resources are organically combined with ' dynamic' cultural information, the traditional folk cultural capital gain path is expanded, and adjustment and optimization of the traditional cultural tourism resources can be facilitated.