专利名称 | T CELL RECEPTORS | ||
申请号 | IN201817041887 | 申请日 | |
公开(公告)号 | IN201817041887A | 公开(公告)日 | 2018-11-05 |
申请(专利权)人 | 发明人 | TRIBBLE Nicholas; LAWRANCE William; BAGG Eleanor | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to T cell receptors (TCRs) which bind the HLA-A0201 restricted peptide GVYDGREHTV (SEQ ID NO : 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs cells engineered to present the TCRs cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs nucleic acids or cells of the invention. |
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