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专利概况
专利名称
申请号 RU2017103887 申请日
公开(公告)号 RU2017103887A3 公开(公告)日 2017-02-06
申请(专利权)人 发明人
专利来源 国家知识产权局 转化方式
摘要

The invention relates to the field of medicine, in particular to novel peptides having biocidal properties, more particularly antibacterial, antifungal and antiviral properties, and preparations based thereon. Proposed are a biocidal peptide of general formula Y-Ile-Leu-Pro-X-Lys-X-Pro-X-X-Pro-X-Arg-Arg-NH2, where X is 4-nitrophenylalanine; 4-chlorophenylalanine; 4-methoxyphenylalanine; D-phenylalanine; 4-aminophenylalanine; 4-aminobenzoylphenylalanine; homophenylalanine; 4-tertbutylphenylalanine; 2-methylphenylalanine; 4-fluorophenylalanine; pentafluorophenylalanine; or 2-trifluoromethylphenylalanine; and Y is H or palmitoyl or aminodecanoyl, and a preparation in the form of a gel with biocidal properties, containing, as an active substance, said peptide at a concentration of 0.001 to 0.1 wt%. The claimed peptides demonstrate biocidal properties towards bacteria, including spore-forming bacteria, mould fungi, and also viruses. The peptide-based gels can be used for treating bacterial and viral infectious diseases and infectious comorbidities.

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