Field of use : The invention relates to nucleotide chemistry and makes it possible to synthesize new combinatorial libraries of supramolecular oligonucleotides for use in medicine, cosmetology, and pharmacy, including for the creation of anti-aging agents for the body; for the treatment of such human diseases as cancer and trophic ulcers; and for the creation of new herbicides and pesticides. Essence of the invention : Combinatorial RNA oligonucleotide derivatives, characterized in that they are produced by covalently modifying initial RNA oligonucleotides by simultaneous combinatorial carboxylation and formylation of their constituent exocyclic adenine, guanine, and cytosine amino groups and ribose alcoholic residue in a combinatorial synthesis reaction to produce the greatest number of different derivatives, and as a result of the synthesis, a combinatorial mixture of derivatives of each oligonucleotide is formed that is then used whole, without separation into fragments, to create biologically active compositions. Technical result : Modified complementary protected RNA oligonucleotides that have anti-aging, anti-cancer and other properties and on the basis of which a medicinal, veterinary, agrochemical or cosmetic product can be obtained that has a broad spectrum of activity. The agent has a broad spectrum of action and low toxicity, and is suitable for industrial production.