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专利概况
专利名称 METHOD FOR PRODUCING A CONDENSED ADHESIVE PHASE OF SILK FUSION PROTEINS
申请号 WOFI18050460 申请日
公开(公告)号 WO2018229341A1 公开(公告)日 2018-06-13
申请(专利权)人 发明人 LINDER Markus; MOHAMMADI Pezhman; ARANKO Sesilja
专利来源 国家知识产权局 转化方式
摘要

The present invention is directed to a method for producing a condensed phase of a silk fusion protein, the method comprising the steps of preparing a solution of a silk fusion protein in an aqueous medium and concentrating said silk fusion protein in said aqueous medium, wherein said fusion protein is isolated from a recombinant production host and comprises a silk-like protein sequence and two separate non-silk terminal module sequences, such as cellulose binding modules, SpyCatcher domains, tenth type III module of Fibronectin, gamma- crystallin D, flanking said silk-like protein sequence; wherein the method is performed so that said silk fusion protein is not precipitated and subsequently dissolved to said aqueous medium.The present invention is also directed to using such fusion proteins as adhesives.

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