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专利概况
专利名称 METHOD FOR PREDICTION OF RISK OF EXTERNAL GENITAL ENDOMETRIOSIS
申请号 RU2017138355 申请日
公开(公告)号 RU2675698C1 公开(公告)日 2017-11-02
申请(专利权)人 发明人 Kublinskij Konstantin Sergeevich; Urazova Olga Ivanovna
专利来源 国家知识产权局 转化方式
摘要

FIELD : medicine.SUBSTANCE : invention relates to the field of medicine, namely to gynecology, and is a method for predicting the risk of developing external genital endometriosis, consisting in the fact that DNA is isolated from peripheral venous blood, followed by the study of polymorphic variants C-511T of the IL1B gene, C-590T of IL4 gene, G-174C of IL6 gene, C-592A of IL10 gene, C-509T of TGFB gene, -604T/C of KDR gene, 735G/A of Ang-2 gene, and A-4889G of CYP1A1 gene, C-734A of CYP1A2 gene and calculate the value of P according to the formula : P=eY/(1+eY), where P – is the value of the probability of development of the trait, Y – is the value of the regression equation, calculated by the formula : Y = -45.807+k1+k2+k3+k4+k5+k7+k8+k9; where ki is chosen depending on polymorphic variants of genes; and if the value of P is equal to or greater than 0.5, a high risk of developing external genital endometriosis is predicted, and if the value of P is less than 0.5, a low risk of developing external genital endometriosis is predicted.EFFECT : method provides a prediction of the risk of developing external genital endometriosis, which makes it possible for the timely start of treatment of this disease.1 cl, 2 ex

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