| 专利名称 | 6-alkyl dihydropyrazolopyrimidinone compounds as PDE2 inhibitors | ||
| 申请号 | US15574411 | 申请日 | |
| 公开(公告)号 | US10160762B2 | 公开(公告)日 | 2016-05-24 |
| 申请(专利权)人 | 发明人 | Dong Ming Shen; Michael P Dwyer; Christopher J Sinz; Deping Wang; Shawn J Stachel; Daniel V Paone; Ashley Forster; Richard Berger; Yili Chen; Yimin Qian; Shimin Xu; Chunmei Hu; William D Shipe; Jianmin Fu; Zhigang Guo; Haitang Li; Yingjian Bo | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson' s disease, Parkinson' s disease dementia (PDD), or Huntington' s disease, and those associated with striatal hypo-function or basal ganglia dysfunction. |
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