您好,欢迎来到海南中小企业大数据中心及公共服务平台!     请登录   免费注册
专利概况
专利名称 SYNTHESIS METHOD FOR DIFLUORODEUTEROMETHOXY(THIO) FUNCTIONAL GROUP-CONTAINING AROMATIC COMPOUND
申请号 WOCN17090937 申请日
公开(公告)号 WO2018232777A1 公开(公告)日 2017-06-29
申请(专利权)人 发明人 WU Yusheng; GENG Yang; ZOU Dapeng; LI Jingya; NIU Chengshan; ZHENG Maolin; LIANG Apeng
专利来源 国家知识产权局 转化方式
摘要

A synthesis method for an aromatic compound containing a difluorodeuteromethoxy functional group or a difluorodeuterothio functional group. In the presence of an alkali, a difluorocarbene donor and Ar-(XH)n and heavy water undergo a reaction to produce a deuterated product Ar-(XCF2D)n, the difluorocarbene donor being BrCF2PO(OR)2 or (chlorodifluoromethyl)trimethylsilane or (bromodifluoromethyl)trimethylsilane, and the alkali being selected from Na, K, Li, Mg, Zn, Al, NaH, KH, LiH, LiAlH4, KOD, NaOD, NaOMe, NaOEt, NaOBu, sodium carbonate, potassium carbonate and cesium carbonate. The method has the advantages of cheap and easily available raw materials, simple and mild reaction, high yield, high deuteration rate, and production amplification easiness.

参与列表

主管部门:海南中小企业服务 | 建设单位:海南商业联合会

版权所有:海南商业联合会 | 备案号:粤ICP备13083911号(ICP加挂服务)@2017