专利名称 | SYNTHESIS METHOD FOR DIFLUORODEUTEROMETHOXY(THIO) FUNCTIONAL GROUP-CONTAINING AROMATIC COMPOUND | ||
申请号 | WOCN17090937 | 申请日 | |
公开(公告)号 | WO2018232777A1 | 公开(公告)日 | 2017-06-29 |
申请(专利权)人 | 发明人 | WU Yusheng; GENG Yang; ZOU Dapeng; LI Jingya; NIU Chengshan; ZHENG Maolin; LIANG Apeng | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
A synthesis method for an aromatic compound containing a difluorodeuteromethoxy functional group or a difluorodeuterothio functional group. In the presence of an alkali, a difluorocarbene donor and Ar-(XH)n and heavy water undergo a reaction to produce a deuterated product Ar-(XCF2D)n, the difluorocarbene donor being BrCF2PO(OR)2 or (chlorodifluoromethyl)trimethylsilane or (bromodifluoromethyl)trimethylsilane, and the alkali being selected from Na, K, Li, Mg, Zn, Al, NaH, KH, LiH, LiAlH4, KOD, NaOD, NaOMe, NaOEt, NaOBu, sodium carbonate, potassium carbonate and cesium carbonate. The method has the advantages of cheap and easily available raw materials, simple and mild reaction, high yield, high deuteration rate, and production amplification easiness. |
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