An azaaryl derivative having a structure of formula (I), a preparation method therefor, and an application thereof for use in pharmacy. The series of compounds of the present invention can be widely applied to the preparation of drugs for treating cancer, tumor, autoimmune diseases, metabolic diseases, or metastatic diseases, in particular for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic diseases, neurodegenerative diseases, metastasis of primary tumor sites, or bone metastatic cancers, and are expected to be developed into a new generation of CSF1R inhibitor drugs.