The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Zika virus or a disorder related to such an infection. In particular the present invention concerns a Zika virus vaccine. The present invention is directed to an artificial nucleic acid polypeptides compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease first and second medical uses of the artificial nucleic acid polypeptides compositions and vaccines. Further the invention is directed to a kit particularly to a kit of parts comprising the artificial nucleic acid polypeptides compositions and vaccines.