专利名称 | METHOD OF QUANTITATIVE DETERMINATION OF 8-(TRIFLUOROMETHYL)BENZO[f][1, 2, 3, 4, 5]PENTATHIEPIN-6-AMINE HYDROCHLORIDE IN BIOLOGICAL MEDIA | ||
申请号 | RU2018123244 | 申请日 | |
公开(公告)号 | RU2676487C1 | 公开(公告)日 | 2018-06-27 |
申请(专利权)人 | 发明人 | Leonov Klim Andreevich | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
FIELD : medicine.SUBSTANCE : invention relates to the field of medicine, namely pharmacology and toxicology, and can be used to determine 8-(trifluoromethyl)benzo[f][1, 2, 3, 4, 5]pentathiepin-6-amine hydrochloride in biological media. Method involves the extraction of the analyte with a 0.4?% solution of formic acid in acetonitrile, followed by its determination by high-performance liquid chromatography-mass spectrometry with isocratic elution mode using as the mobile phase a mixture of a solution of trifluoroacetic acid and a 0.1?% solution of formic acid in methanol in a ratio of 20 : 80.EFFECT : using this method allows you to determine the quantitative content of 8-(trifluoromethyl)benzo[f][1, 2, 3, 4, 5]pentathiepin-6-amine hydrochloride to study the pharmacokinetics of the drug on the basis of this substance.1 cl, 3 tbl, 4 ex |
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