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专利概况
专利名称 METHOD OF QUANTITATIVE DETERMINATION OF 8-(TRIFLUOROMETHYL)BENZO[f][1, 2, 3, 4, 5]PENTATHIEPIN-6-AMINE HYDROCHLORIDE IN BIOLOGICAL MEDIA
申请号 RU2018123244 申请日
公开(公告)号 RU2676487C1 公开(公告)日 2018-06-27
申请(专利权)人 发明人 Leonov Klim Andreevich
专利来源 国家知识产权局 转化方式
摘要

FIELD : medicine.SUBSTANCE : invention relates to the field of medicine, namely pharmacology and toxicology, and can be used to determine 8-(trifluoromethyl)benzo[f][1, 2, 3, 4, 5]pentathiepin-6-amine hydrochloride in biological media. Method involves the extraction of the analyte with a 0.4?% solution of formic acid in acetonitrile, followed by its determination by high-performance liquid chromatography-mass spectrometry with isocratic elution mode using as the mobile phase a mixture of a solution of trifluoroacetic acid and a 0.1?% solution of formic acid in methanol in a ratio of 20 : 80.EFFECT : using this method allows you to determine the quantitative content of 8-(trifluoromethyl)benzo[f][1, 2, 3, 4, 5]pentathiepin-6-amine hydrochloride to study the pharmacokinetics of the drug on the basis of this substance.1 cl, 3 tbl, 4 ex

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