本发明系有关制备下列式I之杂环衍生化合物的新方法；上述方法中使用的新中间体化合物；一种用於治疗或预防高尿酸血症、痛风症、肾炎、慢性肾衰竭、肾结石、尿毒症、尿石症或与尿酸有关的疾病之组成物，该组成物包括式I化合物，以剂量大於2mg至10mg或较低，每日一次口服给药；及新的式I化合物之盐酸盐1.5水合物(倍半水合物)： The present invention relates to a new process for preparing a heterocycle derivative compound of the following Formula I; a new intermediate compound used in the above process; a composition for the treatment or prevention of hyperuricemia, gout disease, nephritis, chronic renal failure, nephrolithiasis, uremia, urolithiasis, or a disease associated with uric acid, which comprises the compound of Formula I at a dose of greater than 2 mg to 10 mg or less and is orally administered once daily; and a new hydrochloride 1.5 hydrate (sesquihydrate) of the compound of Formula I :