An amide compound of formula (I), a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotope variant, a hydrate, or a solvate thereof, a pharmaceutical composition containing the compound, and a pharmaceutical use thereof. The compound and the pharmaceutical composition have excellent protein kinase inhibitory activity and good pharmacokinetic properties, can increase drug concentrations of the compound in animals, and improve the efficacy and safety of the drug.