专利名称 | PREPARATION METHOD OF NEW COMPOUND OF 4' -THIONUCLEOSIDE AND INTERMEDIATE IN THE PREPARATION METHOD | ||
申请号 | WOCN18091514 | 申请日 | |
公开(公告)号 | WO2019001292A1 | 公开(公告)日 | 2018-06-15 |
申请(专利权)人 | 发明人 | ZHOU Jiangfeng; LIANG Yufeng; WANG Qiang; WANG Tao; HAN Weibiao; LI Youqiang; WEI Haidong; GE Jianhua; ZHAO Zhongqiong; WEN Qianying; WU Lingjing; TIAN Qiang; ZHAO Mingliang; ZENG Hong; CAI Jiaqiang; WANG Lichun; WANG Jingyi | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
A method for preparing a compound of formula T-3 according to route I is disclosed. The method comprises the following steps : a first step of reacting a compound of formula T-1 with a reagent comprising a PG group in the presence of an organic base or an inorganic base, optionally under the catalysis of a catalyst, to form a compound of formula T-2; and a second step of reacting the compound of formula T-2 under the catalysis of an organic base or an inorganic base to form the compound of formula T-3. A method for preparing a compound of formula (I)-1 according to route II is further disclosed. The method comprises the following steps : step A, reacting T-3 with R-1 in the presence of a hydroxyl hydrogen removal reagent to obtain a compound of formula T-4; and step B, reacting the compound of formula T-4 under the catalysis of an organic base or an inorganic base, or in the presence of a fluorine-containing reagent, to obtain the compound of formula (I)-1. In addition, an intermediate in the above preparation methods is further disclosed. |
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