Provided are a [1, 2, 4] triazol [4, 3-a] pyridine derivate shown in the general formula (I), a preparation method therefor, and a pharmaceutical composition containing the derivate, wherein the pharmaceutical composition is used as a therapeutic agent, and especially, used as a c-Met inhibitor and an immunosuppressant; and each substituent in the general formula (I) is same as that defined in the specification.