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专利概况
专利名称 CRYSTALLINE FORM OF BTK KINASE INHIBITOR AND PREPARATION METHOD THEREOF
申请号 US16067229 申请日
公开(公告)号 US20190010161A1 公开(公告)日 2016-12-20
申请(专利权)人 发明人 Guaili WU; Zhenjun QIU; Xi LU; Yun LU
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to a crystalline form of a BTK kinase inhibitor and the preparation method thereof. In particular, the present invention relates to a crystal form I of (R)-4-amino-1-(1-(but-2-ynoyl)pyrrolidin-3-yl)-3-(4-(2, 6-difluorophenoxy)phenyl)-1H-pyrrolo[2, 3-d]pyridazin-7(6H)-one (the compound of formula (I)) and the preparation method thereof. The crystal form I of the compound of formula (I) obtained by the present invention has a good crystalline stability and chemical stability, and the crystallization solvent used has a low toxicity and low residue, thus making it more suitable for use in clinical treatment.

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