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专利概况
专利名称 A quinazoline derivative of the crystal and its preparation
申请号 JP2018533210 申请日
公开(公告)号 JP2019500370A 公开(公告)日 2016-12-23
申请(专利权)人 发明人 シュー チューティエン; ワン チンユアン; ワン チェンホア
专利来源 国家知识产权局 转化方式
摘要

The invention relates to Crystal form I and Crystal form II of dihydrochloride of N-(4-((3-chloro-4-fluorophenyl)amino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazoli n-6-yl)acrylamide represented by the following Formula (I), and preparation methods therefor, wherein the Crystal form I has an X-ray powder diffraction pattern having characteristic peaks at the 2 ? positions of 6.0?.2? 7.3?.2? 11.7?.2? 12.9?.2? 18.4?.2? 24.7?.2? and 26.3?.2? as determined by using Cu-K?radiation, and the Crystal form II has an X-ray powder diffraction pattern having characteristic peaks at the 2 ? positions of 5.0?.2? 7.0?.2? 10.1?.2? 17.0?.2? 26.0?.2? and 26.5?.2? as determined by using Cu-K?radiation.

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