专利名称 | The crystal form of the BTK kinase inhibitor and method of manufacture | ||
申请号 | JP2018530708 | 申请日 | |
公开(公告)号 | JP2019500357A | 公开(公告)日 | 2016-12-20 |
申请(专利权)人 | 发明人 | ウ、グアイリ; チユ、ジェンジュン; ルウ、シー; ルウ、ユン | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to a crystalline form of a BTK kinase inhibitor and the preparation method thereof. In particular, the present invention relates to a type I crystal of (R)-1-(3-(4-amino-3-(4-(2, 6-difluorophenoxy)phenyl)-7-hydroxy-1H-pyrorolo[2, 3-d]py ridaz-1-yl)pyrrolidin-1-yl)butyl-2-alkyne-1-ketone (the compound in formula (I)) and the preparation method thereof. The type I crystal of the compound of formula (I) obtained by the present invention has a good crystal stability and chemical stability, and the crystal solvent used has a low toxicity and residue, thus making same more suitable for use in clinical treatment. |
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