您好,欢迎来到海南中小企业大数据中心及公共服务平台!     请登录   免费注册
专利概况
专利名称 The crystal form of the BTK kinase inhibitor and method of manufacture
申请号 JP2018530708 申请日
公开(公告)号 JP2019500357A 公开(公告)日 2016-12-20
申请(专利权)人 发明人 ウ、グアイリ; チユ、ジェンジュン; ルウ、シー; ルウ、ユン
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to a crystalline form of a BTK kinase inhibitor and the preparation method thereof. In particular, the present invention relates to a type I crystal of (R)-1-(3-(4-amino-3-(4-(2, 6-difluorophenoxy)phenyl)-7-hydroxy-1H-pyrorolo[2, 3-d]py ridaz-1-yl)pyrrolidin-1-yl)butyl-2-alkyne-1-ketone (the compound in formula (I)) and the preparation method thereof. The type I crystal of the compound of formula (I) obtained by the present invention has a good crystal stability and chemical stability, and the crystal solvent used has a low toxicity and residue, thus making same more suitable for use in clinical treatment.

参与列表

主管部门:海南中小企业服务 | 建设单位:海南商业联合会

版权所有:海南商业联合会 | 备案号:粤ICP备13083911号(ICP加挂服务)@2017