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专利概况
专利名称 CRYSTALLINE FORM OF BTK KINASE INHIBITOR AND PREPARATION METHOD THEREFOR
申请号 WOCN18095573 申请日
公开(公告)号 WO2019011316A1 公开(公告)日 2018-07-13
申请(专利权)人 发明人 WU Guaili; QIU Zhenjun; PAN Lianjie; LU Yun
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to a crystalline form of a BTK kinase inhibitor and a preparation method therefor. In particular, the present invention relates to a type II crystal of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-(2, 6-difluorophenoxy)phenyl)-1, 6-dihydro-7H-pyrrolo[2, 3-d]pyridazin-7-one (a compound of formula (I)) and a preparation method. The type II crystal of the compound of formula (I) obtained by the present invention has good chemical stability and crystal form stability, and is also better used for clinical treatment as the used crystallization solvent has a low toxicity and low residues.

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