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专利概况
专利名称 3, 5 - Diphenyl - diazole compound soluble derivative
申请号 JP2018532323 申请日
公开(公告)号 JP2019501167A 公开(公告)日 2016-12-14
申请(专利权)人 发明人 アルミン・ギーゼ; フェリクス・シュミット; クリスティアン・グリージンガー; アンドレイ・レオーノフ; セルゲイ・リャザーノフ
专利来源 国家知识产权局 转化方式
摘要

The therapeutic effect is caused by the inhibition of the protein aggregation in the affected tissue, such as the brain. 3, 5-Diphenyl-diazole derivatives have been shown to be effective in inhibiting aggregation of proteins but are also characterized by their poor solubility in aqueous solutions. The prodrugs of the invention are modified 3, 5-diphenyl-diazole derivatives, which are characterized by their improved solubility in aqueous solutions, and by their increased bioavailability.

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