专利名称 | USP30 1 - cyanopyrrolidine derivative as inhibitor of | ||
申请号 | JP2018527919 | 申请日 | |
公开(公告)号 | JP2019501142A | 公开(公告)日 | 2016-11-29 |
申请(专利权)人 | 发明人 | マーク イアン ケンプ; マーティン リー ストックリー; アンドリュー マディン | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylatingenzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein R1, R 2, R 3, m, L and X are as defined herein. |
主管部门:海南中小企业服务 | 建设单位:海南商业联合会
版权所有:海南商业联合会 | 备案号:粤ICP备13083911号(ICP加挂服务)@2017