专利名称 | PRODUCTION METHOD FOR EXTERNAL MEDICINE WHICH IS FOAMY IN USE | ||
申请号 | JP2018160897 | 申请日 | |
公开(公告)号 | JP2019006799A | 公开(公告)日 | 2018-08-29 |
申请(专利权)人 | 发明人 | MASUDA TAKAAKI; KOBAYASHI KOICHI | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
PROBLEM TO BE SOLVED : To provide means for solving the problems on a dosage form, such as foam formation properties and a side effect, in an external pharmaceutical composition which contains a polar solvent in an amount sufficient for solubilizing a hardly water-soluble drug and is foamy in use. SOLUTION : A method for producing an external pharmaceutical composition which contains 1) a polar solvent, 2) a nonionic surfactant, and 3) a polyhydric alcohol, and which is foamy in use and is used in an aspect not accompanied by washing action comprises a heating and stirring step of the mixture containing 1) to 3), a confirmation step of solubilization of the mixture, a cooling step of the solubilization-confirmed mixture to room temperature in stirring, and a filling up step of the cooling step-experienced mixture into a non-gas type foamer container, the polar solvent being N-alkyl pyrrolidone and the like having an alkyl chain having 1 to 4 carbon atoms, the nonionic surfactant being a fatty acid monoglyceride and the like, the polyhydric alcohol being 1, 3-butylene glycol and the like, only the nonionic surfactant being comprised as a surfactant. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT |
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