PROBLEM TO BE SOLVED : To provide cell populations useful for modulating various peripheral immune functions, methods for preparing the cell populations, and methods for their use. SOLUTION : A composition is obtained by : (a) providing a culture of mesenchymal stem cells; (b) contacting the cell culture of step (a) with a polynucleotide comprising sequences encoding a Notch intracellular domain (NICD); (c) selecting cells that comprise the polynucleotide of step (b); and (d) further culturing the selected cells of step (c) in the absence of selection. SELECTED DRAWING : Figure 2 COPYRIGHT : (C)2019, JPO&INPIT