专利名称 | Polypeptide molecule with improved dual specificity | ||
申请号 | DE102017115966 | 申请日 | |
公开(公告)号 | DE102017115966A1 | 公开(公告)日 | 2017-07-14 |
申请(专利权)人 | 发明人 | Martin Hofmann; Felix Unverdorben; Sebastian Bunk; Dominik Maurer | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to a bispecific polypeptide molecule, polypeptide chain comprising a first and a second polypeptide chain, providing a binding region, which is derived from a T cell receptor (a TCR), is for a peptide epitope, bound to a major histocompatibility complex (MHC class), to recruit specific to a binding region, which is derived from an antibody, capable of, human immune effector cells, specifically binds to a surface antigen by these cells, and the method of producing the bispecific polypeptide molecule and their use. |
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