FIELD : biotechnology.SUBSTANCE : present invention relates to the field of biotechnology, specifically to an insulin protein conjugate with an immunoglobulin Fc region, and can be used in medicine. Invention allows to obtain an conjugate of insulin with immunoglobulin, in which its constituent parts are site-selectively linked by a covalent bond through a non-peptide polymer-linker.EFFECT : conjugate of the present invention has higher receptor activity and improved pharmacokinetic characteristics.29 cl, 4 dwg, 1 tbl, 4 ex