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专利概况
专利名称 T cell receptor (TCR)- expressing exogenous virus specific non - activated T cells
申请号 KR1020187031670 申请日
公开(公告)号 KR1020190006952A 公开(公告)日 2016-03-31
申请(专利权)人 发明人 BERTOLETTI ANTONIO; KOH SARENE
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to T cells, in particular a non-activated T cell, comprising an exogenous nucleic acid encoding a T cell Receptor (TCR) specific for a virus. An embodiment of the invention is directed to a non-activated (resting) T cell expressing Hepatitis B virus (HBV) envelope s183-191 TCR capable of inhibiting viral replication and which shows reduced expression of perforins and/or granzymes in response to stimulation as compared to an activated T cell expressing the said TCR. Also encompassed are methods for producing such cells, compositions, pharmaceutical compositions and kits comprising such cells and medical uses thereof.

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