FIELD : medicine.SUBSTANCE : invention relates to medicine and method for producing heterogeneous preparation based on papain having regenerative properties, comprising treating the ion exchange fiber matrix of VION AN-1 or VION KH-1 with papain solution, incubating. For immobilization of the VION KH-1, an acetate buffer or borate buffer with the addition of KCl is used, and for the immobilization on VION AN-1, a tris-glycine or glycine buffer. Incubation is carried out for 24 hours at room temperature. Precipitate formed is washed with the buffer used in immobilization until the protein in the washing waters is absent.EFFECT : invention provides reduction in consumption of the wound healing agent due to high stability of the preparation at temperatures above the physiological and its prolonged action.1 cl, 4 dwg, 1 ex