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专利概况
专利名称 17 Β - hydroxysteroid dehydrogenase type 1 inhibitors as therapeutic active [...] derivatives
申请号 JP2016522680 申请日
公开(公告)号 JP6456373B2 公开(公告)日 2014-06-25
申请(专利权)人 发明人 ヒルベラ リーナ; カンガス ラウリ; コスキミエス パシ; ラミンタウスタ リスト; ウンキラ ミッコ
专利来源 国家知识产权局 转化方式
摘要

The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2, R3, R4, R7 and R8 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD1 and in treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17β-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds or pharmaceutically acceptable salts thereof.

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