专利名称 | METHOD FOR PRODUCING A STABLE PHARMACEUTICAL COMPOSITION PRESENTED AS AN AQUEOUS SOLUTION | ||
申请号 | ARP170102733 | 申请日 | |
公开(公告)号 | AR109775A1 | 公开(公告)日 | 2017-09-29 |
申请(专利权)人 | 发明人 | ||
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The invention relates to the chemical and pharmaceutical industry. A method for producing a stabilized pharmaceutical composition in the form of an aqueous solution comprising active ingredients which include succinic acid, inosine, nicotinamide and riboflavin mononucleotide sodium salt, wherein a stabilizing agent is further introduced into the composition as one or more pharmaceutically acceptable ingredients selected from the group consisting of sodium hydroxide, tris-(oxymethyl)aminomethane (TRIS), ethanolamine, diethanolamine, sodium carbonate and meglumine to obtain a stable aqueous solution having a pH value in the range of 6.0 to 8.0; the method further comprises a sterilizing filtration of the resulting dissolved composition, and an additional thermal sterilization at temperatures from 100癈 and an exposure time of 8 minutes to 116癈 and an exposure time of 2 minutes. |
主管部门:海南中小企业服务 | 建设单位:海南商业联合会
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