| 专利名称 | As inhibitor of TAFIa large cyclic urea derivatives, their preparation and use as medicine | ||
| 申请号 | JP2016517597 | 申请日 | |
| 公开(公告)号 | JP6461113B2 | 公开(公告)日 | 2014-06-05 |
| 申请(专利权)人 | 发明人 | アンドレアス・エバース; クリストファー・カルス; ミヒャエル・ワーグナー; ヘルムート・ヴィーラン | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). The invention further relates to the process for the preparation of the compounds of formula I and to the use thereof as medicaments. |
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