Synthetic drug development is slow and costly often running into the billions of dollars. While the benefits of various abundant and inexpensive natural products including natural oils and extracts have been postulated and speculated upon for centuries there has been very little success in achieving national approval (e.g. FDA approval) of natural compounds so that they can be used to benefit animals and patients. As many natural products are often complex and heterogenous appropriate technologies for rapidly and efficiently predicting efficacy and toxicity of such natural compounds has been sorely lacking. Thus there has been a long held and still unmet need to determine and teach appropriate health veterinary and medical uses for an orange frankincense and cannabis products in a costeffective and efficient manner. Accordingly the present invention teaches compositions manufacture products and methods of use prevention and treatment using at least one extract selected from the group comprising orange frankincense cannabis or other natural oil or extract or at least one substance or compound isolated from said at least one oil or extract (e.g. a cannabinoid sesquiterpene monoterpene an ester ether aldehyde phenylpropene alcohol ketone phenol etc.) so as to benefit medicine human health and veterinary care. For example the present invention teaches the use of at least one extract selected from the group comprising orange frankincense cannabis or other natural oil or extract or at least one substance or compound isolated from said at least one oil or extract to reduce miR21 expression and thus treat/prevent cancer and psoriasis.