| 专利名称 | GLP-1 derivatives and uses thereof | ||
| 申请号 | US14897738 | 申请日 | |
| 公开(公告)号 | US10195255B2 | 公开(公告)日 | 2014-06-19 |
| 申请(专利权)人 | 发明人 | Steffen Reedtz Runge; Per Sauerberg; Jacob Kofoed; Ingrid Pettersson; Christian W Tornoee | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The invention relates to a derivative of a GLP-1 analogue, optionally C-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an OEG-like linker element; wherein these elements are interconnected via amide bonds and attached to a Lys residue of the GLP-1 analogue. The invention also relates to intermediate products in the form of novel GLP-1 analogues incorporated in the derivatives of the invention, as well pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration. |
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