FIELD : medicine.SUBSTANCE : present invention relates to the field of medicine, veterinary medicine and is an ointment for the treatment of thermal burns applied against the background of external gamma irradiation, containing biologically active substances and an ointment base. Ointment for the treatment of radiation-thermal burns is described, containing biologically active substances and an ointment base, characterized in that it contains ichthyol and dimexidum as biologically active substances, and as an ointment base – petrolatum at the following ratios of components, wt.% : ichthyol – 28–30; dimexidum – 18–20; vaseline – 50–54. Method of treatment and radiation-thermal burns is also described, comprising applying a therapeutically effective amount of the above ointment to the burned surface, the application is carried out once every 5 days for 35 days and kept on the affected area without dressing.EFFECT : development of an agent with increased antimicrobial activity for the treatment of radiation-thermal burns IIIB and IV degree without the use of dressings, which allows to increase the effectiveness of treatment and reduce healing time due to a synergistic effect by 20 days.2 cl, 1 dwg, 9 ex