FIELD : medicine; pharmaceuticals.SUBSTANCE : invention relates to the pharmaceutical industry and medicine, in particular to a method for the prevention of long-term pain in the late postoperative period in patients with connective tissue dysplasia. Method of the prevention of long-term pain syndrome in the late postoperative period in the patients with connective tissue dysplasia, while a month before the planned operation in the morning, at lunch and in the evening, 150 grams of fresh corn bran flour with the addition of infusion of amaranth before baking at the rate of 1.5 g of dry leaves per 100 g of bread and taking Chinese magnolia tincture at the rate of 12 drops per 100 g of bread in combination with “Vitrum”, 1 tablet 3 times a day.EFFECT : above method is effective for the prevention of long-term pain in the late postoperative period in the patients with connective tissue dysplasia.1 cl, 2 ex