| 专利名称 | FORMULATION FOR BISPECIFIC T-CELL ENGAGERS (BITES) | ||
| 申请号 | RU2015121574 | 申请日 | |
| 公开(公告)号 | RU2679124C2 | 公开(公告)日 | 2013-11-05 |
| 申请(专利权)人 | 发明人 | OLBRIKH Karsten; BUNTE Tomas; VINTER Jonas; PETERS Jerg; TRILL Tomas | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
FIELD : medicine; pharmaceuticals.SUBSTANCE : group of inventions relates to the field of medicine, specifically to clinical pharmacology, and is intended to maintain the stability of a liquid pharmaceutical composition. Liquid pharmaceutical composition comprises a polypeptide, TRIS, phosphate, and a lyoprotectant. Said polypeptide comprises an amino acid sequence represented in SEQ ID NO : 8. Composition has pH from 5.0 to 7.5. Components are used in claimed amounts. Also provided is a solid mixture obtained by lyophilising said liquid composition. In addition, a reconstituted liquid pharmaceutical composition is provided, which is obtained by dissolving said lyophilised solid mixture in a suitable liquid medium.EFFECT : use of the group of inventions improves the stability of a liquid pharmaceutical composition by preventing the formation of undesirable polypeptide aggregates.12 cl, 22 tbl, 22 ex |
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