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专利概况
专利名称 FORMULATION FOR BISPECIFIC T-CELL ENGAGERS (BITES)
申请号 RU2015121574 申请日
公开(公告)号 RU2679124C2 公开(公告)日 2013-11-05
申请(专利权)人 发明人 OLBRIKH Karsten; BUNTE Tomas; VINTER Jonas; PETERS Jerg; TRILL Tomas
专利来源 国家知识产权局 转化方式
摘要

FIELD : medicine; pharmaceuticals.SUBSTANCE : group of inventions relates to the field of medicine, specifically to clinical pharmacology, and is intended to maintain the stability of a liquid pharmaceutical composition. Liquid pharmaceutical composition comprises a polypeptide, TRIS, phosphate, and a lyoprotectant. Said polypeptide comprises an amino acid sequence represented in SEQ ID NO : 8. Composition has pH from 5.0 to 7.5. Components are used in claimed amounts. Also provided is a solid mixture obtained by lyophilising said liquid composition. In addition, a reconstituted liquid pharmaceutical composition is provided, which is obtained by dissolving said lyophilised solid mixture in a suitable liquid medium.EFFECT : use of the group of inventions improves the stability of a liquid pharmaceutical composition by preventing the formation of undesirable polypeptide aggregates.12 cl, 22 tbl, 22 ex

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