FIELD : medicine.SUBSTANCE : invention relates to the field of medicine and is a method for predicting severe acute necrotizing pancreatitis by determining the concentration of a marker in the serum of venous blood, characterized in that the concentration of transthyretin in the serum of venous blood is used as a marker, venous blood is taken on the 5–7th day from the moment of the disease, then, according to the concentration of transthyretin in the serum of the venous blood, the type of the disease is predicted, transthyretin value <14 mg/dl, the development of severe acute necrotizing pancreatitis is predicted.EFFECT : invention provides fast and accurate prediction of severe acute necrotizing pancreatitis.1 cl, 2 ex, 2 tbl