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专利概况
专利名称 NON-ACTIVATED T CELLS EXPRESSING EXOGENOUS VIRUS-SPECIFIC T CELL RECEPTOR (TCR)
申请号 EP16897247 申请日
公开(公告)号 EP3436572A1 公开(公告)日 2016-03-31
申请(专利权)人 发明人 BERTOLETTI Antonio; KOH Sarene
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to T cells, in particular a non-activated T cell, comprising an exogenous nucleic acid encoding a T cell Receptor (TCR) specific for a virus. An embodiment of the invention is directed to a non-activated (resting) T cell expressing Hepatitis B virus (HBV) envelope s183-191 TCR capable of inhibiting viral replication and which shows reduced expression of perforins and/or granzymes in response to stimulation as compared to an activated T cell expressing the said TCR. Also encompassed are methods for producing such cells, compositions, pharmaceutical compositions and kits comprising such cells and medical uses thereof.

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