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专利概况
专利名称 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2, 4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
申请号 EP15813831 申请日
公开(公告)号 EP3237406B1 公开(公告)日 2015-12-18
申请(专利权)人 发明人 BREBION Franck Laurent; ALVEY Luke Jonathan; AMANTINI David; DEPREZ Pierre Marc Marie Joseph; GOSMINI Romain Luc Marie; JARY Hel鑞e Marie; PEIXOTO Christophe; VARIN Marie Laurence Claire; DE CEUNINCK Fr閐閞ic Andr? POP BOTEZ Iuliana Ecaterina
专利来源 国家知识产权局 转化方式
摘要

The present invention discloses compounds according to formula I : Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.

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