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专利概况
专利名称 STABLE DOSAGE FORM OF ETIDRONATE-CYTARABINE CONJUGATE, AND USE THEREOF
申请号 US15780384 申请日
公开(公告)号 US20190038559A1 公开(公告)日 2016-11-28
申请(专利权)人 发明人 Ekaterina Alekseevna IVANOVA; Alexander KARPEISKY; Shawn P ZINNEN; Lisa Lynn CARALLI; Rina Diana SALURIALAM
专利来源 国家知识产权局 转化方式
摘要

The invention relates to the field of medicine and pharmaceuticals and particularly to a novel dosage form of an antitumor preparation, which ensures the hydrolytic and physical stability of said preparation, as well as to a method for producing a dosage form of this type. The stable dosage form is a lyophilizate comprising an etidronate-cytarabine conjugate or a pharmaceutically acceptable salt thereof, and a stabilizer, which is a divalent metal salt, in a molar ratio of stabilizer to conjugate of 1 : 1 to 20 : 1. A dosage form of this type ensures the hydrolytic and physical stability of the conjugate during long-term storage, and the stability of solutions of the conjugate for parenteral administration during clinical use.

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