Suggested is an extract of Coprinus comatus obtained or obtainable according to the following protocol : (a) providing a source of dry biomass of Coprinus comatus; (b) extracting said source of biomass with water, C1-C4 aliphatic alcohols or mixtures thereof; (c) separating the extract thus obtained from the remaining cell material; and optionally (d) repeating steps (b) and (c) once or twice, which is particularly useful for regulating the pilosebaceous unit of a human.