专利名称 | 3-O-SULFAMOILOXY-6-OXA-7Β-METHYL-D-HOMO-8Α-ESTRA-1, 3, 5(10)-TRIEN-17Α-ONE APPLICATION FOR THE BREAST CANCER TREATMENT, INCLUDING THE TRIPLE NEGATIVE FORM, AND ITS PRODUCTION METHOD | ||
申请号 | RU2018139335 | 申请日 | |
公开(公告)号 | RU2679625C1 | 公开(公告)日 | 2018-11-08 |
申请(专利权)人 | 发明人 | Shavva Aleksandr Grigorevich; Morozkina Svetlana Nikolaevna | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
FIELD : medicine.SUBSTANCE : group of inventions relates to the field of medicine and the chemical and pharmaceutical industry, and concerns the breast cancer treatment means. Proposed is the 3-O-sulphamoyloxy-7β-methyl-D-homo-6-oxa-8α-estra-1, 3, 5(10)-trien-17a-one production method, and its use as the antitumor agent in the triple negative breast cancer mono- and adjuvant therapy.EFFECT : mammary gland ER-/PR-/HER2+ tumors growth inhibition in mice and in the triple negative breast cancer MDA-MB-231 cells growth suppression.3 cl, 1 tbl, 2 ex |
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