The present invention relates to the technical field of medical compounds, and relates to an oxidized ?1, 4-oligoglucuronic acid, and a preparation method therefor and uses thereof. In the present invention, by using abundant starch, especially soluble starch, in the natural world as the raw material, all 6-site hydroxyl groups of the starch ?1, 4-polyglucose are oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2, 2, 6, 6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.