专利名称 | Pharmaceutical containing iodine complex and [...] | ||
申请号 | JP2018507334 | 申请日 | |
公开(公告)号 | JPWO2017164172A1 | 公开(公告)日 | 2017-03-21 |
申请(专利权)人 | 发明人 | 金井 求; 相馬 洋平; 倪 積智; 谷口 敦彦 | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to A?peptides but also to other amyloids, and a preventive/therapeutic drug for an amyloid-related disease using the same. A curcumin-boron complex represented by the following formula (1) : wherein X 1 and X 2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X 3 represents a bromine atom, an iodine atom, or a selenium atom; R 1 and R 2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R 3 and R 4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R 1 and R 3 or R 2 and R 4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R 5 and R 6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R 7 and R 8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R 5 and R 7 or R 6 and R 8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof. |
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