Disclosed is a pharmaceutical composition including naftazone or one of its pharmaceutically acceptable salts, for its use for the pulsatile release of naftazone or one of its pharmaceutically acceptable salts, wherein : a first pulse of naftazone or one of its pharmaceutically acceptable salts is released substantially immediately upon oral administration of the pharmaceutical composition; and at least one additional pulse of naftazone or one of its pharmaceutically acceptable salts is released at about 3 hours to about 8 hours following the oral administration.