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专利概况
专利名称 For improved safety and efficacy of chimeric antibody using TNF CHO cell glycosylation
申请号 JP2018535858 申请日
公开(公告)号 JP2019504065A 公开(公告)日 2017-01-10
申请(专利权)人 发明人 ジェフリー・スー; ジアン・ツァオ
专利来源 国家知识产权局 转化方式
摘要

There is disclosed a chimeric infliximab-like monoclonal antibody having at least 80% NANA glycosylation terminal sialic acid and a glycosylation pattern of Gal-α(2, 3/6)-Gal that binds to tumor necrosis factor alpha (TNF). The disclosed infliximab-like monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of SEQ ID NO. 1/SEQ ID NO. 2) as infliximab (Remicade®) which has at least 80% NGNA terminal sialic acid and a glycosylation pattern of Gal-α(1, 3)-Gal.

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