| 专利名称 | For improved safety and efficacy of chimeric antibody using TNF CHO cell glycosylation | ||
| 申请号 | JP2018535858 | 申请日 | |
| 公开(公告)号 | JP2019504065A | 公开(公告)日 | 2017-01-10 |
| 申请(专利权)人 | 发明人 | ジェフリー・スー; ジアン・ツァオ | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
There is disclosed a chimeric infliximab-like monoclonal antibody having at least 80% NANA glycosylation terminal sialic acid and a glycosylation pattern of Gal-α(2, 3/6)-Gal that binds to tumor necrosis factor alpha (TNF). The disclosed infliximab-like monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of SEQ ID NO. 1/SEQ ID NO. 2) as infliximab (Remicade®) which has at least 80% NGNA terminal sialic acid and a glycosylation pattern of Gal-α(1, 3)-Gal. |
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